Monocyte-Derived Suppressor Cells in Transplantation
نویسندگان
چکیده
منابع مشابه
Monocyte-Derived Suppressor Cells in Transplantation
Myeloid-derived suppressor cells (MDSC) are cells of myeloid origin with enhanced suppressive function. They are negative regulators of the immune responses and comprise a heterogeneous mixture of immunosuppressive cells of monocytic (M-MDSC) and granulocytic (G-MDSC) origin. A more recent nomenclature proposes the term "suppressive monocyte derived cells" (suppressive MCs) to define CSF1/CSF2-...
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Human peripheral blood monocytes (HPBM) were cultured in the absence of human serum and were converted into a state exhibiting a high accessory function expressed by their ability of supporting lymphocyte proliferation. After a prolonged culture in serum free media the monocyte derived cells were highly viable, increased in size and developed veils and dendritiform elongatio'l1s. Paralleli...
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Submit Manuscript | http://medcraveonline.com granulocytes, dendritic cells (DC) and immature myeloid cells (IMC) [1-3]. There are many researches on tumor MDSCs and negative effect on immune system [4,5]. Because of the negative regulation of immune response through different ways, MDSCs related researches are performed by transplant immunologists [6,7]. Many research find that MDSCs can preve...
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Background: Regulatory T Cells (Tregs) and Myeloid-Derived Suppressor Cells (MDSCs) are two main regulatory cells modulating the immune responses in inflammation and cancer. Objective: To investigate and compare Tregs and MDSCs in peptic ulcer and gastric cancer. Methods: Patients with dyspepsia were selected and divided into three groups of non-ulcer dyspepsia (NUD, n=22), peptic ulcer disease...
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Accumulating evidence suggests that myeloid-derived suppressor cells (MDSCs) underpin an immunological checkpoint that is activated during inflammation or "inflammatory-like" conditions like cancer. Here, we discuss the identification of MDSCs in patients receiving allogeneic hematopoietic stem cell transplantation and their potential as therapeutic targets or tools for improving the efficacy o...
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ژورنال
عنوان ژورنال: Current Transplantation Reports
سال: 2015
ISSN: 2196-3029
DOI: 10.1007/s40472-015-0054-9